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Molecular Profiles Expands Capsule Capabilities

Adds capsule bander for liquid filling and a second capsule filling machine

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By: Kristin Brooks

Managing Editor, Contract Pharma

Molecular Profiles Ltd. has expanded its capsule filling capabilities at its clinical manufacturing site in the UK, adding a capsule bander that allows the company to offer liquid filling into capsules, along with its existing powder and semi-solid filling capability. The company also added a second capsule filling machine that provides increased capacity, greater capsule fill weight range and improved fill weight accuracy.
 
Dr. Rob Harris, chief technical officer at Molecular Profiles, said, “The investment in capsule banding is a natural extension to our oral dosage form manufacturing capabilities and will allow us to produce liquid-in-capsule formulations, which can be particularly beneficial for poorly soluble and potent compounds. Given that many early phase trials tend to involve capsules, our new filling machine gives us much greater dosage flexibility. We can manufacture for relatively small scale early stage trials and also now have the enhanced capacity that allows us to scale up to Phase III.”
 
Molecular Profiles also recently invested in GMP hot melt extrusion (HME) technology to its service portfolio for processing poorly soluble molecules.

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